About the
Ozcan Lab

We are a multi-national team dedicated to the understanding and treatment of obesity and obesity-related diseases. Our laboratory is located within the Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School.

The primary aim of the laboratory is to delineate the molecular mechanisms of endoplasmic reticulum (ER) stress originated pathologies in obesity. The two main focus areas are insulin and leptin receptor signaling and their crosstalk with the unfolded protein response pathway.

Dr. Ozcan's group employs a multi-disciplinary approach that draws from mouse genetics, endoplasmic reticulum physiology & pathophysiology, biochemistry, chemical biology and proteomics to identify key metabolic pathways that determine the cell’s response to physiologic and pathophysiologic ER stress. The ultimate goal of this integrated approach is to unravel the potential therapeutic targets in the unfolded protein response (UPR) pathway in order to manipulate cellular energy metabolism and find a cure for obesity and its related diseases.


The Team

Principal Investigator

Umut Ozcan M.D.

Postdoctoral Research

Xudong Feng Ph.D.

Feifei Zhang Ph.D.

Dongxian Guan Ph.D.

Manisha Thaker


Xiao Yu


Research Technologist

Mario Salazar B.A.

Research Assistant

Lamia Faruk

Masters Student

Tianhao Zhu

Ozcan Laboratory

Center for Life Science • 3 Blackfan Circle, Boston, MA 02115

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