IL1R1 is required for celastrol's leptin-sensitization and antiobesity effectsFeng X, Guan D, Auen T, Choi JW, Salazar Hernández MA, Lee J, Chun H, Faruk F, Kaplun E, Herbert Z, Copps KD, Ozcan U. Nature Medicine. 2019 Mar 4. doi: 10.1...
PGC-1α functions as a co-suppressor of XBP1s to regulate glucose metabolism. Lee J, Salazar Hernández MA, Auen T, Mucka P, Lee J, Ozcan U. Molecular Metabolism, 2017 Oct 28. pii: S2212-8778(17)30737-8 PubMed: https://www.ncbi.nlm.ni...
Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes. Sharabi K, Lin H, Tavares CD, Dominy JE, Camporez JP, Perry RJ, Schilling R, Rines AK, Lee J, Hickey M, Bennion M, Palmer M, Nag PP, Bittker JA, Perez J, J...
Inflammation Improves Glucose Homeostasis through IKKβ-XBP1s Interaction. Liu J, Ibi D, Taniguchi K, Lee J, Herrema H, Akosman B, Mucka P, Salazar Hernandez MA, Uyar MF, Park SW, Karin M, Ozcan U. Cell, 2016 Nov 3; 167(4): 1052-10...
Withaferin a is a leptin sensitizer with strong antidiabetic properties in mice. Lee J, Liu J, Feng X, Salazar Hernandez MA, Mucka P, Ibi D, Choi J, Ozcan U. Nature Medicine, 2016 August 1 PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27...
XBP1s is an antilipogenic protein. Herrema H, Zhou Y, Zhang D, Salazar Hernandez MA, Shulman GI, Ozcan, U. Journal of Biological Chemistry, 2016 June 20 PubMed: https://www.ncbi.nlm.nih.gov/p...
Treatment of Obesity with Celastrol. Liu J, Lee J, Salazar Hernandez MA, Mazitschek R, Ozcan U. Cell, 2015 May 21; 161(5):999-1011 PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26000480
BRD7 regulates XBP1’s activity and glucose homeostasis through its interaction wit the regulatory sPark SW, Herrema H, Salazar M, Cakir I, Cabi S, Basibuyuk Sahin F, Chiu YH, Cantley LC, Ozcan U. Cell Metabolism, 2014 Jul 1;20(1):73-84 PubMed: https://www...
Mom’s milk molds neural wiring for metabolism. Cakir I, Ozcan U. Cell, 2014 Jan 30;156(3):396-7 PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24485448
Unfolded protein response signaling and metabolic diseases. Lee J, Ozcan U. J Biol Chem, 2014 Jan 17;289(3):1203-11 PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24324257
IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance. Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U. IRS1Ser307 phosphorylation does not mediate mTORC1-induced insulin resistance. Biochem Biophys Res C...
Mitofusins: mighty regulators of metabolism. Ozcan U. Cell, 2013 Sep 26;155(1):17-8 PubMed: https://www.ncbi.nlm.nih.gov/pubmed/24074856
Epinephrine deficiency results in intact glucose counter-regulation, severe hepatic steatosis and Sharara-Chami RI, Zhou Y, Ebert S, Pacak K, Ozcan U, Majzoub JA. Int J Biochem Cell Biol. 2012 Jun;44(6):905-13 PubMed: https://www.ncbi.nlm.nih.gov/pubmed...
p38 MAPK-mediated regulation of Xbp1s is crucial for glucose homeostasis. Lee J, Sun C, Zhou Y, Lee J, Gokalp D, Herrema H, Park SW, Davis RJ, Ozcan U. Nature Medicine, 2011 Sep 4;17(10):1251-60 PubMed: https://www.ncbi.nlm.nih....
Regulation of Glucose Homeostasis Through XBP1-FoxO1 interaction. Zhou Y, Lee J, Reno CM, Chung J, Sun C, Park SW, Chung J, Lee J, White MF, Biddinger S, Fisher SJ, Ozcan U. Nature Medicine, 2011 Mar;17(3):356-65 PubMed: ...
Sarco(endo)plasmic reticulum Ca2+-ATPase 2b is a major regulator of endoplasmic reticulum stress anPark S, Zhou Y, Lee J, Lee J, Ozcan U. PNAS, 2010 Nov 9;107(45):19320-5 PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20974941
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nucleaPark S, Zhou Y, Lee J, Lu A, Sun C, Chung J, Ueki K, Ozcan U. Cell Metabolism, 2014 Jul 1;20(1):73-84. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/20348926
Endoplasmic Reticulum Stress Plays A Central Role in Development of Leptin Resistance. Ozcan L, Ergin AS, Sarkar S, Lu A, Chung J, Nie D, Myers MG, Jr., Ozcan U. Cell Metabolism, 2009 Jan 7;9(1):35-51. PubMed: https://www.ncbi.nlm.nih.gov/pu...
